You might be familiar with the term "brain cells", with people often saying silly phrases such as "I'm going to loose brain cells if I keep talking to you!" or "My last two brain cells fighting for third place during a test" (I've definetly used both :3). Though in more formal settings, you might hear the term "neuron." But neuron is not the only term used to describe cells within the brain. There are actually many different types of "brain cells"!
And yes, all of them perform different functions from eachother. Just like out bodies are made up of muscle cells, skin cells, and bone cells, our brain also includes different types of cells that do different things. Our bodies wouldn't be able to perform all the vital functions that they do if all our cells did the same thing. The brain, just like our bodies, has many vastly different sub functions that all do different, essential things that otherwise wouldn't be possible if all out "brain cells" had the same function! Let's dive in!
Examples of different types of Brain Cells:
Neurons
Glial Cells (basically any type of supporting brain cell that is NOT a neuron)
Astrocytes
Oligodendrocytes
Schwann Cells
Ependymal Cells
Microglia
*Don't panic if the names are intimidating!! All will be explained below!
Neurons
Here is a lovely diagram I found online; I will link the image credits if I find them!
Neurons are responsible for communicating information across the central and peripheral nervous systems using both electrical and chemical signals (*will be expanded on later!!). From the image above, we can identify the different parts of a neuron:
Cell body (sometimes referred to as the Soma): This is where the nucleus, genetic material and other organelles are located! A lot of neurotransmitters are also produced here, though they can also be produced in the presynaptic terminal (labeled as "Axon Terminal" in the diagram).
Dendrites & Axon Terminals: Dendrites are the branchlike formations that come out of the cell body. They go hand in hand with the "Axon Terminal" because throughout our bodies, neurons are usually connected to each other in order to effectively spread messages until they reach the CNS (central nervous system). Specifically, the axon terminals connect to the dendrites. These points of connection are known as synapses (shown in the image to the right).
Axon: The tail-like projection that goes away from the cell body/soma. and branches out into the axon terminals.
Myelin Sheath & Schwann Cells: The myelin sheath is responsible for coating the axon (serving almost like insulation) and making electric nerve impulses (known as "action potentials") travel faster. These electric impulses travel from node (Node of Ranvier) to node much quicker when the axon is properly myelinated. This jumping process is known as "saltatory conduction."
The green sections are where one neuron connects to another, and the space between the presynaptic neuron and postsynaptic neuron is known as the "synaptic cleft" (can also be referred to as the "synaptic space"). This will be further expanded on below!
Image taken from: Synapse Structure – Foundations of Neuroscience
From one Neuron to another
Like we saw earlier, a neuron that precedes a synapse is known as a "presynaptic" neuron, while a neuron that succeeds a synapse is known as a "postsynaptic" neuron. However, the coolest thing here is the space in between, known as the synaptic cleft!! Many actions take place here, but this is also where chemical messages are relayed from one neuron to another (or, if you want to be fancy, "the axon terminals of the presynaptic neuron" to the "dendrites of the postsynaptic neuron")!
Check out the image on the right! The blue blob on the left represents the presynaptic neuron and the purple blob on the left represents the postsynaptic neuron.
Now, there are two different kinds of synapses: Electrical and Chemical.
Now look at the second image of the two different types of synapses. The image on the right depicts a chemical synapse, hence the neurotransmitters (little blue balls) and receptors (the three purple things on the right blob). Chemical synapses are slower than electrical synapses, because they physically involve the transfer of physical proteins to a variety of receptors that are present on both the presynaptic and postsynaptic neurons (will be covered in more detail later!!)
On the other hand, as seen in the image on the left, in an electrical synapse, signals can go both ways. Unlike in a chemical synapse, the space between two neurons is usually referred to as a "gap junction" and ions are transferred from one neuron to another to change the charges of either neuron, a process known as polarization.
For extra information or a better definition, check out this fabulous video on synapses by Neuroscientifically Challenged: https://www.youtube.com/watch?v=k5RafiYXieo
A synaptic cleft (the space between the two blobs) along with respective neurotransmitters and receptors.
Image taken from: https://www.biorender.com/template/synaptic-cleft-horizontal
Image taken from: Chemical synapses - Labster
Different types of Neurons?!!
Okay, now that we've just covered what a neuron is and looks like, I bet you'll be quite bewildered to find out that there are actually different types of neurons! And yes, they do different things. Oh, and the one up there (with the purple stem and yellow Schwann cells) is a typical example of a multipolar neuron. There are three different types that people generally refer to:
Unipolar/Pseudounipolar
Bipolar
Multipolar
Glial Cells
Scientists used to assume that many Glial Cells, especially astrocytes, simply just served as "glue" to hold other cells, mainly neurons together. However, more recent studies have started to repeatedly show that they do indeed serve other crucial functions in the brain.
Astrocytes are the most common and versatile type of Glial Cell and are mainly present in the CNS (central nervous system) which means the brain and spinal cord. They are star shaped cells that kind of resemble brittle stars or "sea anemone". They are usually found between neurons and blood vessels, and they serve as a sort of bridge/messenger between the capillaries and the neuron to transfer and exchange important resources. They also play a very important role in the BBB (Blood Brain Barrier), which will be covered soon!!
At the blood vessel side, they:
Take in oxygen and glucose from the blood, while also serving as a protective barrier cell in the Blood-Brain Barrier (will be covered later, too!!)
Once they reach the neuron side, they:
Deliver vital nutrients or other nutrients they received from the capillaries, or at the synaptic cleft, they remove/recycle any excess neurotransmitters or excess ions that may still be floating around after a chemical message has finished being transmitted (again we will go over what happens in this process soon!)
The blue tube on the left represents a capillary and the green thing in the middle is an astrocyte connecting to a neuron (the blue thing on the right).
Image from: https://www.nature.com/articles/s44324-025-00090-1?utm_
Oligodendrocytes are depicted as the little orange popcorn-like cells to the right of the neuron in the diagram above. And just as shown in the image above, one of the main functions of oligodendrocytes is to make myelin, the material that coats/insulates axons and allows impulses to travel faster along nerves. They wrap their projections/branches around axons on neurons within the CNS to produce myelin and contribute to axon insulation.
Myelin is a fatty tissue made up of mostly lipids and some proteins, which is why it appears white. In fact, white matter (the section of the brain that contains myelinated neurons and allows for fast nerve impluses and signals to travel quickly throughout the CNS) in the brain is white because of all the myelin around the axons of the neurons within it!
As seen in the image to the right, the "gray matter" (the darker pink regions) in the superficial regions of the brain is known as the cerebral cortex and is responsible for thinking/processing and "problem solving," while the white matter is responsible for sending the right signals and information to ensure the thinking and problem solving can happen in the first place. Because most of the neurons in the gray matter regions are unmyelinated, it is the job of the regions with the myelinated neurons ("white matter") to relay signals and information quickly and efficiently.
This is a cross section of the brain, and the white matter can clearly be seen branching out and connecting to the "gray matter," which is the pinker regions on the superficial parts of the brain.
Image from: Nervous Systems | Organismal Biology
Schwann Cells ("Shwaun")
Schwann Cells are very similar to oligodendrocytes! In fact, the main difference between the two is that oligodendrocytes are responsible for myelinating the neurons of the central nervous system (CNS), while Schwann Cells myelinate the neurons of the peripheral nervous system (PNS). Another key difference is that Schwann Cells only myelinate a single axon, while Oligodendrocytes can do several, in fact, up to 50 different axons!
Ependymal Cells ("Eppendi-mul")
Ependymal Cells serve as barrier cells that surround ventricles (open spaces within the brain that hold cerebrospinal fluid/CSF). They also have these hair-like projections on them known as cilia (they are also found in our tracheas, and help "brush up" dirt and other particles that are stuck on the tracheal walls). They also line ventricles/cavities in the spinal cord, meaning they are found in many locations specifically within the central nervous system (CNS).
In the two images to the right, the central canal is a tube-like passageway that goes through the spinal cord and holds cerebrospinal fluid within it. The image on the bottom shows a cross section of the spinal cord and the respective location of the central canal. In the top right image, we can also see the ependymal cells around the ventricle, and if we look close enough, even the hair-like projections of the cilia!!
Microglial Cells
Microglial cells are like the brain's personal immune/regulator cells, because the regular immune system is cut off from the brain. They check on nearby neurons to ensure they are functioning well and also act like phagocytes (a type of immune cell that swallows/engulfs foreign objects such as bacteria and pathogens via phagocytosis) when they encounter any foreign objects or pathogens within the CNS!
Want to test your knowledge with a quiz?
You can do so here: https://forms.gle/Zv46HpGUvSRjaB4n6
The "central canal" represents a ventricle filled with CSF. Bottom image from: https://neuroscientificallychallenged.com/glossary/central-canal